Fig. 5
Expression alteration of tRNA modification enzymes, ARSs, and translation factors across cancer types. a Two-sided χ2 test for up-regulated and down-regulated enzymes for tRNA modification enzymes (left), aminoacyl tRNA synthetases (middle), and translation factors (right). b Differentially expressed tRNA modification enzymes between paired tumor and normal samples. Magenta denotes up-regulation; blue denotes down-regulation. X-axis represents 16 cancer types with > 5 tumor-normal paired RNA-seq samples. Squares denote enzymes with expression alterations. c Differentially expressed aminoacyl tRNA synthetases (ARSs) between paired tumor and normal samples. Left panel, cytosolic ARSs (cy-ARSs); right panel, mitochondrial (mt-ARSs). The color bars in the middle panel summarize the comparisons between paralog ARSs. Squares denote enzymes with expression alterations. d Differentially expressed translation factors between paired tumor and normal samples. Squares denote enzymes with expression alterations
