Table 1 Phenotypes with significant single parent-of-origin associations
From: Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree
Phenotype | rsid (effect allele/other allele) | chr:loc | Variant location | Nearest gene | MAF | N | Beta (SE) | Paternal GWAS p-value | Maternal GWAS p-value | Standard GWAS p-value |
|---|---|---|---|---|---|---|---|---|---|---|
A Maternal associations | ||||||||||
Age of menarche | rs7184983 (A/G) | 16:56554709 | Upstream | BBS2 | 0.059 | 336 | 0.862 (0.154) | 5.01E–01 | 3.11E–08 | 6.75E–03 |
CIMT | rs4077567 (G/A) | 2:216703202 | Intronic | LINC00607 (noncoding RNA gene) | 0.30 | 429 | 0.047 (0.008) | 5.72E–01 | 3.02E–08 | 4.21E–06 |
FEV1 | rs9849387 (A/G) | 3:77764243 | Intergenic | ROBO2 | 0.39 | 1029 | −0.089 (0.015) | 3.87E–01 | 4.10E–09 | 4.38E–04 |
rs6791779 (C/G) | 3:74996505 | Intergenic | MIR4444-1 (noncoding RNA gene) | 0.24 | 879 | −0.102 (0.021) | 6.88E–02 | 1.48E–08 | 4.52E–02 | |
LVMI | rs574232282 (G/A) | 1:41662388 | Intronic | SCMH1 | 0.018 | 537 | 0.239 (0.042) | 5.52E–01 | 1.39E–08 | 1.05E–03 |
B Paternal Associations | ||||||||||
LDL | rs12024326 (A/G) | 1:227146433 | Intronic | ADCK3 | 0.175 | 686 | −0.295 (0.048) | 8.06E–10 | 4.21E–01 | 4.24E–05 |
rs4843650 (A/G) | 16:87683486 | Intronic | JPH3 | 0.448 | 621 | 0.211 (0.036) | 6.57E–09 | 2.21E–01 | 1.50E–04 | |
SBP | rs1536182 (A/G) | 13:46275415 | Upstream | LINC01055 (noncoding RNA gene) | 0.2 | 684 | −0.028 (0.005) | 1.53E–08 | 1.78E–01 | 6.93E–04 |
Total cholesterol | rs113588203 (G/T) | 1:228979156 | Intergenic | RHOU | 0.099 | 703 | −0.341 (0.060) | 1.76E–08 | 7.43E–02 | 8.08E–03 |
