Table 2 Variants, tagging regions, significantly associated with the first morbidity hazard (end of healthspan) in 300,447 GCW-British individuals, and results of replication in 96,313 individuals

From: Identification of 12 genetic loci associated with human healthspan

SNP

Chr

Position (bp)

EA

RA

EAF

beta

P

β rep

P rep

rs10197246

2

202,204,741

C

T

0.734

−0.033

3.67e-09

−0.035

2.43e-04

rs12203592

6

396,321

T

C

0.214

0.063

1.80e-25

0.043

2.10e-05

rs1049053

6

32,634,405

T

C

0.671

0.037

1.40e-11

0.013

1.46e-01

rs10455872

6

161,010,118

G

A

0.081

0.057

4.11e-10

0.027

1.19e-01

rs140570886

6

161,013,013

C

T

0.016

0.116

2.18e-08

0.131

4.09e-04

rs7859727

9

22,102,165

T

C

0.488

0.031

7.41e-10

0.041

1.52e-06

rs34872471

10

114,754,071

C

T

0.292

0.061

9.73e-29

0.062

2.86e-11

rs2860197

10

123,351,302

A

G

0.613

−0.029

1.22e-08

−0.007

4.47e-01

rs1126809

11

89,017,961

A

G

0.304

0.04

2.35e-13

0.017

7.59e-02

rs4784227

16

52,599,188

T

C

0.24

0.032

3.02e-08

0.018

7.75e-02

rs4268748

16

90,026,512

C

T

0.311

0.038

1.55e-12

0.004

6.24e-01

rs159428

20

31,099,311

C

T

0.527

0.028

2.36e-08

−0.005

5.84e-01

  1. EA, effective (coded, tested) allele; RA, reference (non-coded) allele; EAF, effect allele frequency; β, regression coefficient estimate (units of measurement is log(hazard ratio) per allele); p, p-value after adjustment for genomic control; βrep, regression coefficient estimate in replication sample; prep p-value in replication sample. In bold: replicated loci. In italics: locus demonstrating opposite effect in replication
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