Fig. 5
From: Tasmanian devils with contagious cancer exhibit a constricted T-cell repertoire diversity
Expansion of public clonotypes in DFTD-affected devils. a Prevalence of public clonotypes significantly increased in diseased devils. Mann–Whitney U-test statistics and p-values (in parentheses) are shown. Coloured data points represent three pairs of pre- and post-DFTD samples, with the same colour indicating the same animal. b Observed frequencies of top-100 most abundant public clonotypes that showed significantly higher frequencies (Mann–Whitney U test cutoff p < 0.05) in DFTD samples than in non-DFTD samples. c TRBV and TRBJ segment usage among expanded public clonotypes. d Expanded TCRB sequences tend to have a long CDR3 domain compared with the average distribution of CDR3 length across all sequences (dashed line). e Sequence logo showing a high variability within the CDR3 domain in expanded clonotypes
