Fig. 6 | Communications Biology

Fig. 6

From: Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation

Fig. 6

Overexpression of PKM2 exon-10 variants promotes cell proliferation and migration. a, b MCF7 cells were transfected with each HA-PKM2 mutant as indicated, followed by cell number counting over a five-day period (a) and migration assay (b). Representative images of migration are shown (b). c Quantitation of cell migration activity from b (EV vs. wild-type, p = 0.042). Statistical significance was evaluated using the t-test (two-tailed). *p < 0.05; **p < 0.01; ***p < 0.001. Plots are shown in mean ± SD. WT, wild-type

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