Table 2 Allosteric coupling constants of PKM2 variants

From: Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation

Q ax a

FBP

Ser

Phe

Wild-type

11.70 ± 2.62

1.22 ± 0.10

0.09 ± 0.01

H391Y

3.56 ± 0.22

1.35 ± 0.07

0.15 ± 0.01

R399E

4.10 ± 0.62

1.18 ± 0.07

0.22 ± 0.02

  1. aCoupling constant (Qax) is derived from the equation \(K_{\mathrm{a}} = K_{{\mathrm{ia}}}^0\left[ {\left( {K_{{\mathrm{ix}}}^0 + \left[ {{\mathrm{PEP}}} \right]} \right)/\left( {K_{{\mathrm{ix}}}^0 + Q_{{\mathrm{ax}}}\left[ {{\mathrm{PEP}}} \right]} \right)} \right]\).
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