Fig. 8
From: Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics
Schematic of activated cofilin in tauopathy. Under pathological conditions (i.e. Aβ and/or oxidative stress)22,50, oxidation of 14-3-3 releases SSH149, thereby allowing cofilin activation by dephosphorylation. Activated cofilin not only deregulates F-actin dynamics (severing and cofilin–actin aggregation) and promotes mitochondrial dysfunction but also directly competes with tau for binding to microtubules. This results in displacement of tau from microtubules, destabilization of microtubules, and promotion of tauopathy
