Fig. 8
From: Differences in glutamate uptake between cortical regions impact neuronal NMDA receptor activation
Temporal profile of extrasynaptic glutamate clearance is slower in GLAST KO mice in the ACC and BC. a Example traces of iGluSnFr responses in the anterior cingulate cortex (ACC) following synaptic stimulation (single stimulation, 10 × 50 Hz and 10 × 100 Hz) in WT mice (black traces) and GLAST KO mice (GLASTCreERT2/CreERT2 pink traces). b In the ACC, GLAST KO mice show slower kinetics of the events only at 100 Hz compared with WT mice (nWT = 10, nGLAST KO = 11, NWT = 6, NGLAST KO = 3; Psingle = 0.58, P50 Hz = 0.42, *P100 Hz = 0.02). c Same as (a) but in the BC. d In the BC, GLAST KO mice show slower kinetics of the events at both 50 Hz and 100 Hz compared with WT mice (nWT = 14, nGLAST KO = 7, NWT = 6, NGLAST KO = 3; Psingle = 0.26, *P50 Hz = 0.01, *P100 Hz = 0.02). n = number of slices, N = number of mice. Data are mean ± SEM. Two-tailed unpaired t test
