Fig. 3
Suppression of the differentiation of IFN-γ producing iNKT cells in Eomes cKO. a, b Percentage of IFN-γ, IL-4, and IL-17A production by thymic iNKT cells stimulated with PMA and Ionomycin (Iono) in WT and Eomes cKO mice. (n = 6–7, mean ± SEM) c, d As in (a, b), percentage of splenic iNKT cells positive for the indicated cytokines in WT and Eomes cKO mice. (n = 6–7, mean ± SEM) e, f Percentage of splenic iNKT cells positive for IFN-γ, IL-4, and IL-17A production in WT or Eomes cKO 2 h after i.v. administration of α-GalCer (1 μg/mouse) (n = 5–6; data are shown as mean ± SEM). Similar data were obtained from at least three independent experiments. **p < 0.01, Mann–Whitney
