Fig. 1 | Communications Biology

Fig. 1

From: Pharmacological systems analysis defines EIF4A3 functions in cell-cycle and RNA stress granule formation

Fig. 1

Global transcriptomic responses to graded EIF4A3 inhibition. a Workflow to study EIF4A3 functions in HeLa and HCT116 cell lines, treated with multiple concentrations of eutomers (T-595, T-202, blue shading), and an inactive distomer (T-598, white shading). Details in the Methods & Supplementary Note 1). b The top gene expression profiles when treated with eutomers (blue background) and the control distomer (grey background), plotted by normalized gene expression values (vertical axes) at respective inhibitor concentrations (horizontal axes). Each black line traces the response of a single gene, while the red lines represent the consensus response of all genes in the cluster. c Overlap between subsets of monotonically increasing (right) and decreasing (left) responses are shown for the eutomers. Each bar corresponds to the set of events only present in the cell line:inhibitor pairs determined by black circles

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