Fig. 4

Motifs associated with regulation of alternative splicing by EIF4A3. Analysis of RNA binding motifs of known RBPs on EIF4A3 transcripts. Each row represents RBPs binding to a similar RNA motif, enriched (blue) or depleted (red) in the indicated region on the transcript (see Methods) in (a). skipped exon or (b). retained intron monotonically increasing (+) or decreasing (−) events as compared to background alternative spliced events. c Motif hit density of core EJC component Y14, on 200 nucleotide regions adjacent to skipped exon junctions. The vertical axes are the normalized hit rate the the motif can be found at the positions relative to the skipped exon junctions (horizontal axes). For the set of events with increasing and decreasing response profiles, normalized hits are compared against negative (background) samples