Fig. 5
Biological processes affected most by EIF4A3 inhibition. a Enrichment map from gene ontology term enrichment analysis of biological processes. Each node represents a biological process with genes over-represented in the set of monotonically increasing (up, red)/decreasing (down, blue) clusters in the HeLa cell line. Node cores and node rings illustrate the results for T-202 and T-595 compounds, and green and blue edges indicate the overlap between the identified genes of gene sets for T-202 and T-595 compounds, respectively. Biological processes are clustered using EnrichmentMap29 based on the overlap of their monotonic genes. b A comparison between the enrichment scores (x and y axes) of GO terms identified in T-202 and T-595 compound libraries with FDR values < 0.01. Each point represents a BP set enriched in HeLa or HCT116 cell line data
