Fig. 1 | Communications Biology

Fig. 1

From: Wuchereria bancrofti filaria activates human dendritic cells and polarizes T helper 1 and regulatory T cells via toll-like receptor 4

Fig. 1

W. bancrofti sheath antigen induces maturation and activation of human dendritic cells. a–b Expression of dendritic cell-maturation markers upon stimulation of cells with microfilarial sheath antigen (FSAg). LPS was used as a positive control. Representative histograms and mean ± SEM (n = 5 donors) values of expression (% positive cells or median fluorescence intensities, MFI) of CD80, CD86, HLA-DR, CD54, and CD40. c Amount of secretion (mean ± SEM, n = 5) of TNF-α, IL-6, IL-12p70, IL-10, IL-1β, and IL-8 (all in pg/ml) by FSAg-stimulated dendritic cells. *P < 0.05; **P < 0.01; ***P < 0.001; ns, not significant as analyzed by one-way ANOVA test. Abbreviation: Ctr, control

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