Fig. 4 | Communications Biology

Fig. 4

From: Treatment of volumetric muscle loss in mice using nanofibrillar scaffolds enhances vascular organization and integration

Fig. 4

Global gene expression profiles of endothelialized engineered muscle derived from randomly oriented or aligned scaffolds. a Heat map of the top 500 differentially expressed genes by engineered muscle or endothelialized engineered muscle grown in randomly oriented (random) or aligned scaffolds (false discovery rate q-value < 0.05). b Gene Set Enrichment Analysis shows selected gene ontology data sets enriched in the endothelialized engineered muscle derived from aligned scaffolds, in comparison with randomly oriented scaffolds. Gene ontology data sets are shown for myogenesis, oxidative phosphorylation, and tumor necrosis factor-α (TNFA) via nuclear factor κ-light-chain-enhancer of activated B cells (NKFB)

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