Table 1 Radii at critical residues in the ion-conducting pathway of bestrophins

From: Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations

KpBest

cBest1

Residue

Radius (Å)

Residue

Radius (Å)

I62

1.3

I76

1.1

I66

2.2

F80

1.4

F70

2.3

F84

2.3

I180

0.9

V205I

0.9

I180A

3.2

V205

1.3

  1. Radius was calculated based on measuring the distances between five CH3- (C delta on isoleucine or valine, a1–a5) or H- (benzene ring on phenylalanine, b1–b5):
  2. For isoleucine or valine, radius = (a1 + a2 + a3 + a4 + a5)/(5 × 1.17) – 2.00 (van der Waals radius of CH3-)
  3. For phenylalanine, radius = (b1 + b2 + b3 + b4 + b5)/(5 × 1.17) – 1.20 (van der Waals radius of H-)
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