Fig. 5
A gradual increase in algorithm-based and manually measured capillary RBCv with increasing MFI score across all timepoints in the septic shock model (a) is reflected in prediction of capillary perfusion state as defined by per-capillary MFI score ≥2 (b) and normal flow behavior as defined by per-capillary MFI score of 3 (c). RBCv was compared by capillary in the septic shock group (n = 202). Two-way mixed linear model analysis with MFI classification and analysis method as fixed effects and subject number as random effect demonstrated p < 0.0001 for the effect of MFI classification and p = 0.12 for analysis method. Boxplots represent median, interquartile range, and range. RBCv red blood cell velocity, MFI microcirculatory flow index, AUC area under the curve
