Fig. 1
From: Paternal exposure to benzo(a)pyrene induces genome-wide mutations in mouse offspring
Experimental design. Twenty MutaMouse males received 28 daily doses of 0 or 100 mg/kg BaP. The sperm from six controls and six BaP-exposed males were collected 42 days after exposure and analyzed for the presence of lacZ mutations15 and microsatellite mutations17, and for mutation spectrum analysis27. Twelve randomly selected control and BaP-exposed males were mated with untreated C57Bl/6 females 3 and 42 days after the end of the exposure and their offspring analyzed for the presence of single nucleotide variants (SNVs) and copy-number variants (CNVs)
