Fig. 1
a Cell membrane tension as a master regulator of cell shape. Lateral protrusions were suppressed at high tension in favor of one main protrusion, pointing in the direction of migration, therefore increasing the efficiency of movement. A reduction in cell membrane tension allowed lamellipodia to form in multiple directions, reducing the polarity of the cell and its movement. b Working hypothesis of cell movement inhibition by amphipathic peptides. The amphipathic peptide is inserted into the membrane to expand the surface area of the cell membrane, which decreases cell membrane tension. The decrease in cell membrane tension leads to lamellipodium formation in multiple directions, resulting in inhibition of cell movement via FBP17. c Feedback regulation of cell membrane tension by FBP17. FBP17 is recruited to the cell membrane after sensing a reduction in cell membrane tension, thereby promoting actin polymerization. This leads to an increase in cell membrane tension, which releases FBP17 from the cell membrane and suppresses FBP17 from stimulating actin polymerization. Thus, FBP17 may play an important role in sensing and translating cell membrane tension into cell movement and defining front-rear polarity in moving cells
