Fig. 5
From: Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase
Impact of a DSB on RNA polymerase II loading at sites with different H4K16ac levels. a Kinetics of RNA polymerase II loading and dissociation after DSB induction. b RNA polymerase II levels before and after induction of DSB at the different sites on chromosomes. c α-amanitin or actinomycin D treatment does not alter NHEJ frequency at sites with either high or low levels of H4K16ac. d α-amanitin treatment effects on the relative HR frequency. e Actinomycin D treatment effects on the relative HR frequency. f Effect of α-amanitin on recruitment of proteins at different I-SceI sites before and after induction of DSB. (*P < 0.05; **P < 0.01; ***P < 0.001 and ****P < 0.0001, determined by the chi-square test)
