Fig. 3
From: Essential genes shape cancer genomes through linear limitation of homozygous deletions
Correspondence of gene dependency scores with deletion patterns. This figure shows the gene dependency scores from pooled CRISPR-Cas9 screens for 558 cancer cell lines from the Cancer Dependency Map (DepMap AVANA 19Q1) for all genes located in the seven genomic regions where deletion-limitation was detected using copy number data: CDKN2A (a), RB1 (b), MAP2K4 (c), NF1 (d), SMAD4 (e), LINC00290 (f) and PTEN (g). As shown, most of the computationally predicted that were located closest to the deletion targets showed depletion, albeit with varying effect sizes. Genes from Table 1 and Supplementary Table 2 indicated in blue. Remaining genes indicated in black
