Fig. 1 | Communications Biology

Fig. 1

From: A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites

Fig. 1

The kynurenine pathway of tryptophan metabolism. Enzymes are indicated in italics. The neurotoxic metabolites 3-HK and QUIN are highlighted in red and the neuroprotective metabolite KYNA in green. The prodrug 1b is transported across the blood–brain barrier via riboflavin transporters, where it is converted, and thereby releases 1. TDO, tryptophan 2,3-dioxygenase. IDO, indoleamine-2,3-dioxygenase

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