Table 1 Structures and IC50 values of KMO inhibitor compounds

From: A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites

  1. Compounds 9, 11–13 and 16–19 are structurally similar to the KMO inhibitor 6-(3,4-dichlorophenyl) pyrimidine-4-carboxylic acid13, in which the pyrimidine ring of the reported inhibitor is replaced by an isosteric furan ring in 9, 11–13 and 16–19. Compound 8 has been described previously as an inhibitor of KMO32
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