Table 1 Genetic variants at six loci significantly associated with lobar brain volumes

Lobe	Annotation (nearby)	Gene	Rs-ID	Chr	Position	A1	A2	European ancestry meta-analysis				Multi-ethnic meta-analysis				Replication sample (n = 8,789)
								Frq	Effect	SE	p	Frq	Effect	SE	p	N	R² (%)	Frq	Effect	SE	p
Parietal	UTR3	ZIC4	rs2279829	3	147106319	T	C	0.21	−0.92	0.16	5.3 × 10⁻⁹	0.21	−0.95	0.15	4.4 × 10⁻¹⁰	16,015	0.24	0.22	−0.63	0.18	6.0 × 10⁻⁴
Temporal	Intronic	MSRB3	rs146354218	12	65793942	A	G	0.37	0.69	0.11	1.2 × 10⁻⁹	0.37	0.69	0.11	6.4 × 10⁻¹⁰	15,789	0.24	0.37	0.54	0.14	6.4 × 10⁻⁵
Occipital	Intergenic	DAAM1 (dist = 24302)	rs147148763^a	14	59631075	G	GTTGT	0.13	−0.83	0.14	6.6 × 10⁻⁹	0.13	−0.85	0.14	2.9 × 10⁻⁹	15,220	0.23	0.12	−0.80	0.12	3.1 × 10⁻¹¹
Occipital	Intronic	FGFRL1	rs74921869	4	1013382	A	G	0.2	−0.84	0.14	5.9 × 10⁻⁹	0.2	−0.82	0.14	6.2 × 10⁻⁹	12,424	0.27	0.19	−0.22	0.10	3.0 × 10⁻²
Occipital	Intergenic	CENPW (dist = 175626)	rs1337736	6	126845380	A	G	0.23	−0.64	0.12	8.1 × 10⁻⁸	0.23	−0.64	0.12	4.0 × 10⁻⁸	16,016	0.19	0.23	−0.46	0.09	8.0 × 10⁻⁷
Occipital	Upstream	MIR92B/THBS3	rs12411216	1	155164480	A	C	0.46	−0.52	0.10	3.9 × 10⁻⁸	0.46	−0.49	0.09	1.4 × 10⁻⁷	16,016	0.17	0.45	−0.19	0.08	1.6 × 10⁻²

The allele frequency (frq) and effect size are given for A1. Effect sizes are given in units of cm³ per effect allele. Results are provided for the discovery samples and the meta-analysis of all European ancestry and the multi-ethnic meta-analysis. The variance explained gives the percentage variance explained of a SNP¹⁶
A1 effect allele, A2 reference allele, Chr chromosome, Frq effect allele frequency, N number of individuals with genetic variant, p p value, Rs-ID reference SNP cluster ID, SE standard error
^aIn the replication sample, another significant variant in high LD (R² = 0.99) with this variant was used (rs76341705, p value = 4.8 × 10⁻⁹)
Abbreviations: effect allele (A1), reference allele (A2), chromosome (Chr), effect allele frequency (Frq), number of individuals with genetic variant (N), p-value (P), reference SNP cluster ID (Rs-ID), standard error (SE)

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