Fig. 1
From: TRAF6 maintains mammary stem cells and promotes pregnancy-induced mammary epithelial cell expansion
TRAF6 is partially involved in branching of mammary ducts but not essential for mammary gland development during prepuberty. a Whole-mount analysis of mammary tissue of 10-day-old TRAF6-WT and TRAF6-KO female mice. Scale bars, 500 μm. b Branching morphogenesis in mammary tissue of 10-day-old TRAF6-WT and TRAF6-KO mice. Values are means ± SD (TRAF6-WT, n = 13 and TRAF6-KO, n = 13; **p < 0.01). c Populations of CD24highCD49fmid luminal cells (left) and CD24midCD49fhigh basal cells (right) were analyzed using flow cytometry. Mammary epithelial cells isolated from 10-day-old female TRAF6-WT and TRAF6-KO mice were stained for CD24 and CD49f expression. Values are means ± SD (TRAF6-WT and TRAF6-KO, n = 3/group)
