Fig. 9

PFKFB3 expression is positively correlated with EMT and angiogenesis gene expression in a breast cancer clinical database. a The expressional correlation of PFKFB3 with EMT-related genes. b The comparative expression analysis of EMT-related genes between the low- and high-compression groups of breast cancer subtypes. c The expressional correlation of PFKFB3 with angiogenesis-related genes. d The comparative expression analysis of angiogenesis-related genes between the low- and high-compression groups of breast cancer subtypes. Gene expression and correlation were analyzed using a METABRIC dataset in cBioportal database. The correlation coefficients and p-values were obtained by Pearson’s correlation analysis (LumA: PFKFB3-low = 324, PFKFB3-high = 375; LumB: PFKFB3-low = 242, PFKFB3-high = 228; Her2: PFKFB3-low = 135, PFKFB3-high = 86; TN: PFKFB3-low = 227, PFKFB3-high = 193). e The poor prognosis of breast cancer patients with PFKFB3 overexpression. The relation between PFKFB3 expression and breast cancer patient survival was analyzed using Kaplan–Meier Plotter (low:1976 cases, high:1975 cases)⁵³. Source data are provided as Supplementary Data 1