Fig. 4
Aggregation kinetics in CSF. The ThT fluorescence as a function of time (h) for 0.8–10 µM Aβ42 in buffer with a 15% CSF; b 32% CSF; c 66% CSF. The hexagonal figures represent the CSF pool used. d is the calculated t1/2 (h) as a function of Aβ42 concentrations for all CSF concentrations; it is also plotted with a fitted power function, Eq. (1). e is the double log representation of (d). The error bars are the standard deviations from the n = 4 repeats per Aβ42 concentration. The fluorescence data underlying each time trace as well as the t1/2 values and the associated standard deviations can be found in Supplementary Data 3
