Fig. 8
Interaction hot spots. a Docking pose of (R)-1 (CPK color with gray for C-atoms) at ifenprodil binding site of GluN1-1a (purple)/GluN2B (gray) with residues from IZ1 (magenta), IZ2 (green), IZ3 (blue), IZ4 (yellow) and IZ5 (orange). b Heat map for substitution pattern based on structure of (R)-1 and scale bar for IC50 shift factors displayed in Fig. 8c–f. Substituents are colored based on IC50 shifts of 3–7 compared to rac-1. c–f Heat map for amino acid exchange based on the results of activity data for ifenprodil (c), (R)-1 (d), (S)-1 (e) and 2 (f) at mutated NMDARs compared to activity at wildtype NMDARs. Residue color based on IC50 shift factors
