Fig. 2: DBL7ɛ in VAR2CSAM200101. | Communications Biology

Fig. 2: DBL7ɛ in VAR2CSAM200101.

From: Placental malaria vaccine candidate antigen VAR2CSA displays atypical domain architecture in some Plasmodium falciparum strains

Fig. 2

a Schematic representation of VAR2CSA sequence in isolate M200101 with positions of the designed primer pairs (F1-R1 and F2-R2) to amplify fragments encompassing DBL7ɛ. b Gel picture of PCR products representing DBL6ɛ-DBL7ɛ (expected size: 1999 bp) and DBL7ɛ (expected size: 1200 bp) fragments in M200101 samples collected at week 2 (w2) and week 4 (w4) of culture. FCR3 and NF54 showed no amplification of these VAR2CSA fragments. The 3D model of DBL7ɛ predicted by I-TASSER is shown as surface (c) and ribbon (d) highlighting helixes, loops, and sheets. Cysteine residues are shown in red and those involved in disulfide bonds formations are indicated with red spheres.

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