Fig. 1: Virus−glutathione interactions.
From: Glutathione facilitates enterovirus assembly by binding at a druggable pocket
a EV-F3 capsid surface coloured by protein: VP1 blue, VP2 green, VP3 magenta. GSH at Site I is in cyan, and a weaker binding site is shown in white. A pentameric unit and a protomeric unit are both outlined in white and the protomer is coloured bold. b Cartoon of protomeric unit (with adjacent protomers shown in grey) with druggable sites: P orange, I cyan. Protein chains in protomeric unit A coloured as in (a), with VP4 in yellow (barely visible on the inside of the capsid). The position of the fivefold axis is marked “5”. c 15-fold NCS-averaged electron density for GSH, contoured at two levels, the blue level being 2.5 times higher. d GSH at site I. Protomer A is coloured as in (b), protomer B is in grey. The region shown in panel (d) is boxed on panel (b).
