Fig. 3: Distribution of three types of driver mutations in functional protein domains and the association of cancer diversity and drug sensitivity.

a The distribution of driver mutations in the functional domains of three representative genes. The functional protein domains are annotated according to Uniport records. Three types of driver mutations were distinguished by the color and height of the dots in the lollipop plots. SPMs (blue and short), RSMs (green and middle height), and PCMs (red and high). b The drug sensitivity of patients harboring SPMs, RSMs, and PCMs, respectively. The red stars mark statistically significant groups when compared with corresponding negative groups (*p < 0.05, **p < 0.01, two-sided t-test). Drug sensitivity is predicted by IDWAS. c The number of drug-mutation combinations that are significantly associated with drug response. Drug sensitivity data are from IDWAS. d The composition of OncoKB evidence level in three types of mutations. From levels 1 to 4, the strength of evidence for clinical recommendation gradually decreased.