Fig. 4: Cancer diversity driver mutations and cancer evolution.
From: Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes
a Correlation of VAF and network diversity in nine representative genes. Each point represents a TCGA patient. b The overall view of PCCs of VAF and network diversity for genes with different modes of action in cancer. c The comparison of network diversity values in primary tumors (i.e., TCGA group) and advanced tumors (i.e., MSK-IMPACT group). The scatter plot is divided into nine regions corresponding to nine combinations of cancer diversity. d Sankey diagram illustrates the relative flow of cancer diversity changes from primary (TCGA) to advanced (MSK-IMPACT) tumors. e Comparing the distribution of network diversity values between TCGA and MSK-IMPACT. A one-sided t-test was used. f Observed comutations and expected cases in the different combinations of driver mutations.
