Fig. 5: The new cancer genes identified by analyzing SPMs.
From: Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes
a The distribution of SPMs in functional protein domains. Each dot in the lollipop plot represents a patient. The pie plots show the cancer type composition of the patients. b The crystal structure of the protein complex comprised E2F1, TFDP1, and the Rb C-terminal domain (RbC). The PDB file was downloaded from the Protein Data Bank (https://www.rcsb.org/), which was identified as 2AZE. The structure was visualized with Pymol (https://pymol.org/2/) to highlight the 225th residue in TFDP1. RbC (light purple), E2F1 (gray), and TFDP1 (rainbow color, N-terminal to C-terminal is colored from blue to red).
