Fig. 6: Evidence for ancient conserved cancer roles of lncRNAs.

a Functional conservation of human CLC genes was inferred by the presence of Common Insertion Sites (CIS), identified in transposon-mutagenesis screens, at orthologous regions in the mouse genome. Orthology was inferred from Chain alignments and identified using LiftOver utility. b Number of CLC and non-CLC genes that contain human orthologous common insertion sites (hCIS) (see Table 1). Significance was calculated using Fisher’s exact test. c UCSC browser screenshot of a CLC gene (SLNCR1, ENSG00000227036) intersecting a CIS (yellow arrow). d Number of basepairs and number of overlapping hCIS for cancer driver protein-coding genes (CGC), non-cancer driver protein-coding genes (nonCGC), cancer-related lncRNAs (CLC), rest of GENCODE lncRNAS (non-CLC) and the rest of the genome that do not overlap any of the previous element types (intergenic). Arrows indicate the number of hCIS and the percentage for each element type. e Number of overlapping hCIS per megabase of genomic span for each gene class.