Fig. 9: Quantitative analysis of the effect of V127 on PrP fibril formation.
From: Structural effects of the highly protective V127 polymorphism on human prion protein
a Formation of amyloid fibrils as reported by increasing Thioflavin T (ThT) fluorescence. The lines superimposed on the data are non-linear curve fits to Eq. (2), as described in the Methods section. b, c Fibrillogenesis of V127/M129 PrP occurs with significantly longer mean half- and lag times in comparison to WT G127/M129 PrP (P ≤ 0.01, paired t-test). Centre lines show the medians for each data set; box limits indicate the 25th and 75th percentiles as determined by R software (http://shiny.chemgrid.org/boxplotr/); whiskers extend 1.5 times the interquartile range from the 25th and 75th percentiles, outliers are represented by dots. N = 5 sample points for each data set.
