Fig. 2: Heritability estimates.
From: The reliability and heritability of cortical folds and their genetic correlations across hemispheres
Heritability estimates (h2) are mapped, for each bilaterally averaged sulcal descriptor. a The results of the inverse-variance weighted meta-analysis of the heritability estimates across three family-based cohorts QTIM, HCP, and GOBS highlight an overall heritability profile across 3030 individuals. b Heritability estimates (h2) calculated from sulcal features extracted from MRI scans of 10,083 unrelated individuals scanned as part of the UK Biobank were calculated using the genome-wide complex trait analysis (GCTA) package. The regional sulcal metrics that were found to be significantly heritable in the large population sample largely overlap with those found to be most highly heritable across the family-based studies. We highlight only regions that had significant heritability estimates in sulci that had an ICC > 0.75 (see Supplementary Data 2–4 for sulcal-based values of ICC). Significant regions survived Bonferroni correction for multiple comparisons across all bilateral traits and regions (p < 0.05/(61 × 4)); darker red colors indicate higher heritability estimates. The left hemisphere was used for visualization purposes.
