Fig. 3: Bedaquiline alters the conformation of subunits-a and -c.
From: Bedaquiline inhibits the yeast and human mitochondrial ATP synthases
a Structural changes in subunit-a (Helices 5 and 6) caused by the binding of BDQ. The reference structure (gray) is the native without anything bound (pdb: 6CP7). b Structural changes in subunit-c (chains Q and R) caused by the binding of BDQ. The reference structure (gray) is the native without anything bound (pdb: 6CP7). The cryo-EM density is contoured at 4σ with the cryo-EM density attributed to BDQ in red.
