Fig. 2: In-depth SNP analysis of the three candidate gene regions in the Japanese GWAS discovery cohort.
From: Genetic control of CCL24, POR, and IL23R contributes to the pathogenesis of sarcoidosis
Data are shown for a CCL24, b STYXL1-SRRM3, and c C1orf141-IL23R. (Top row) Posterior inclusion probability (PIP) for each SNP, obtained with fine-mapping. (Middle row) Regional association plots for each region. The left y axes represent the −log10 (PGC) values for associations with sarcoidosis; the right y axes (blue lines) represent the estimated recombination rate. The lead SNP in each region is depicted as a purple diamond. The color coding for all other SNPs indicates linkage disequilibrium with the lead SNP, as follows: red, r2 ≥ 0.8; yellow, 0.6 ≤ r2 < 0.8; green, 0.4 ≤ r2 < 0.6; cyan, 0.2 ≤ r2 < 0.4; blue, r2 < 0.2; and gray, r2 unknown. (Bottom row) Gene annotations.
