Fig. 7: Schematic model for the regulation of lipid accumulation in adipocytes by progesterone receptor membrane-associated component 1 (PGRMC1). | Communications Biology

Fig. 7: Schematic model for the regulation of lipid accumulation in adipocytes by progesterone receptor membrane-associated component 1 (PGRMC1).

From: Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes

Fig. 7

When insulin signaling induces adipogenesis, the PGRMC1 gene expression is transactivated by ATF/CREB and PPARĪ³. The heme-dimerized PGRMC1 interacts with LDL-R, VLDL-R, or GLUT4 and facilitates their translocation to the plasma membrane. Consequently, PGRMC1 contributes to lipid accumulation in adipocytes by regulating the lipid uptake via LDL-R or VLDL-R, or de novo fatty acid synthesis.

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