Table 1 Analyses of blood biochemistry of WT and PGRMC1-AKO mice fed ND or HFD.

	WT ND	AKO ND	WT HFD	AKO HFD
TG	54.4 ± 5.6	47.1 ± 2.9	50.2 ± 4.1	81.3 ± 7.1^#,†
Total cholesterol	109.7 ± 1.1	110.0 ± 1.6	134.2 ± 1.3^#	132.1 ± 3.7^#
HDL cholesterol	99.5 ± 1.8	96.7 ± 1.3	109.1 ± 1.2	99.3 ± 1.1
LDL/VLDL cholesterol	10.2 ± 2.0	13.3 ± 2.3	25.1 ± 0.9^#	32.8 ± 2.5^#,†
Glucose (12 weeks)	160.8 ± 4.3	163.6 ± 10.3	189.8 ± 20.3	194.3 ± 10.6
Glucose (16 weeks)	216.8 ± 9.5	221.0 ± 11.2	262.8 ± 7.2^#	277.4 ± 14.2^#
Insulin	1.1 ± 0.3	1.9 ± 0.8	8.6 ± 2.0^#	8.4 ± 2.5^#
AST	18.9 ± 1.5	25.6 ± 0.8	40.1 ± 5.6^#	38.7 ± 3.9
ALT	11.4 ± 0.8	15.2 ± 0.6	24.1 ± 6.5	22.8 ± 5.5

LDL low-density lipoproteins, VLDL, very-low-density lipoproteins, HDL high-density lipoproteins, PGRMC1 progesterone receptor membrane-associated component 1, ND normal diet, HFD high-fat diet, TG triglycerides.
Plasma biochemical parameters were analyzed using WT and PGRMC1-AKO mice after 16 weeks fed ND or HFD. Data are represented as mean ± S.E. Statistical analysis was performed using ANOVA with Tukey’s T test. ^#P < 0.05 (mice fed HFD vs mice fed ND). ^†P < 0.05 (AKO mice fed HFD vs WT mice fed HFD).

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