Fig. 2: Functional enrichment analysis of tumor-associated ORs revealed their potential role in regulating key cancer-related pathways.

a Estimation of the olfactory repertoire at the single-cell resolution revealed previous unreported cancer-associated olfactory receptors, represented here as a Pie Chart. CancerSmell computational workflow identified 59 previously unreported malignant cells-associated ORs. b Gene Set Variation Analysis (GSVA) revealed the functional relevance of the indicated olfactory receptors in tumor-related processes, indicated here as the Alluvial plot. The activated (GSVA score > 0 and corrected p-value < 0.01) and inactivated (GSVA score <0 and corrected p-value < 0.01) status of the indicated biological pathways is represented along the horizontal bar. c Box plots depicting the correlation between GSVA scores and the OR expression in the indicated tumor-related signatures. The X-axis represents the total number of ORs identified to be regulating the indicated biological process. The color of the box represents distinct tumor signatures (mentioned in Panel b of Fig. 2). d Scatter plots representing the correlation between GSVA scores for metastasis signature and OR4F17 in the breast carcinoma cells. The R-value designates the correlation coefficient, whereas the p-value indicates the statistical significance. e Scatter plots representing the correlation between GSVA scores for invasion signature and OR5A1 in the lung adenocarcinoma cells. The R-value designates the correlation coefficient, whereas the p-value indicates the statistical significance.