Table 1 Lead SNPs of loci associated with increased risk of falling (p < 5 × 10−7).

From: Genetic basis of falling risk susceptibility in the UK Biobank Study

Locus

Annotation

Closest gene 

Position

SNP

EA

NEA

EAF

UKBB

Rotterdam Study

B-PROOF

Combined

N = 89,076/362,103

N = 1009/4925

N = 1206/1364

N = 91,219/368,392

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

p

Genome-wide significant loci (P≤5 × 10−8)

 5q21.2

 

RP11-6N13.1

103947968

rs2431108

C

T

0.33

1.03 (1.02–1.04)

9.9 × 10−8

1.13 (1.03–1.25)

0.01

0.98 (0.88–1.10)

0.77

1.03 (1.02–1.04)

4.20 × 10−8

 7p21.3

Intergenic

PER4

9546806

rs2709062

A

G

0.50

1.03 (1.02–1.04)

2.4 × 10−8

1.08 (0.98–1.19)

0.12

1.13 (1.01–1.26)

0.03

1.03 (1.02–1.04)

4.04 × 10−9

 19q12

Intergenic

TSHZ3

31891006

rs2111530

G

A

0.39

1.03 (1.02–1.04)

2.5 × 10−8

1.00 (0.91–1.11)

0.88

1.08 (0.86–1.18)

0.20

1.03 (1.02–1.04)

1.82 × 10−8

Genome-wide suggestive loci (P<5 × 10−7)

 1p13.3

Intergenic

NTNG1

107666942

rs76259395

A

G

0.03

1.03 (1.02–1.05)

6.6 × 10−8

1.03 (0.90–1.19)

0.64

1.02 (0.82–1.26)

0.86

1.03 (1.02–1.05)

6.46 × 10−8

 1p13.2

Intronic

FAM212B

112274162

rs6658723

T

C

0.02

1.02 (1.01–1.03)

2.6 × 10−7

1.00 (0.91–1.11)

0.96

1.01 (0.90–1.11)

0.93

1.02 (1.01–1.03)

3.14 × 10−7

 2p16.1

Intergenic

EIF3FP3

59295476

rs67174662

A

G

0.02

1.02 (1.01–1.03)

5.0 × 10−7

0.99 (0.90–1.10)

0.91

1.02 (0.91–1.14)

0.77

1.02 (1.01–1.03)

5.56 × 10−7

 2p16.1

Intergenic

BCL11A 

60333030

rs974135

T

C

0.33

1.02 (1.02–1.03)

3.9 × 10−7

0.96 (0.87–1.07)

0.51

0.94 (0.83–1.06)

0.34

1.02 (1.01–1.03)

9.45 × 10−7

 3p14.2

Intronic

FHIT 

60138226

rs7616516

A

G

0.07

1.05 (1.03–1.06)

2.3 × 10−7

0.95 (0.79–1.14)

0.56

0.99 (0.85–1.16)

0.92

1.04 (1.03–1.06)

3.49 × 10−7

 5p35.2

Intergenic

DRD1

174888896

rs2471020

C

T

0.59

1.02 (1.01–1.03)

4.8 × 10−7

1.07 (0.97–1.17)

0.20

1.03 (0.92–1.16)

0.61

1.02 (1.01–1.03)

2.43 × 10−7

 6p21.1

Intronic

TRERF1

42360455

rs72857666

T

C

0.03

1.07 (1.04–1.10)

1.5 × 10−7

0.83 (0.61–1.14)

0.26

0.96 (0.68–1.36)

0.81

1.07 (1.04–1.09)

2.85 × 10−7

 7p21.3

Intergenic

NXPH1 

9629549

rs12666565

C

T

0.18

1.03 (1.02–1.04)

4.7 × 10−7

1.06 (0.93–1.21)

0.41

1.13 (0.98–1.31)

0.10

1.03 (1.02–1.04)

1.77 × 10−7

 11p14.1

Intergenic

BDNF 

27643725

rs11030084

C

T

0.03

1.03 (1.02–1.04)

1.1 × 10−7

1.10 (0.96–1.25)

0.16

0.96 (0.91–1.20)

0.55

1.03 (1.02–1.04)

8.92 × 10−8

 11p14.1

Intronic

MPPED2

30492581

rs494221

A

G

0.03

1.03 (1.02–1.04)

6.7 × 10−8

0.98 (0.88–1.08)

0.68

0.88 (0.78–0.98)

0.02

1.02 (1.01–1.03)

3.01 × 10−7

 11p15.5

Intronic

TSPAN4

855372

rs28672671

A

G

0.03

1.03 (1.02–1.04)

5.1 × 10−8

0.95 (0.83–1.07)

0.27

0.89 (0.78–1.01)

0.08

1.03 (1.02–1.04)

2.23 × 10−7

 14.q21.2

Intergenic

RPL10L

46984874

rs12884871

C

T

0.03

1.03 (1.02–1.04)

1.4 × 10−7

1.05 (0.94–1.14)

0.37

0.97 (0.86–1.09)

0.59

1.03 (1.02–1.04)

1.44 × 10−7

 19q12

 

ZNF536 

30772256

rs28633123

T

C

0.21

1.03 (1.02–1.04)

9.4 × 10−8

1.65 (0.93–1.20)

0.37

1.00 (0.87–1.16)

0.96

1.03 (1.02–1.04)

7.29 × 10−7

 20q11.23

Intronic

CTNNBL1

36382855

rs6063547

G

T

0.03

1.03 (1.02–1.04)

6.8 × 10−8

1.06 (0.92–1.21)

0.44

0.99 (0.85–1.16)

0.92

1.03 (1.02–1.04)

6.45 × 10−8

  1. CI confidence interval, EA effect allele, EAF effect allele frequency, NEA non-effect allele, OR odds ratio; p p-value of the SNP falls association.
  2. Lead SNP is defined as SNP with the lowest p-value.
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