Fig. 6: In vivo antibacterial efficacy of 6c against MRSA in murine models of skin wound infection and peritoneal infection. | Communications Biology

Fig. 6: In vivo antibacterial efficacy of 6c against MRSA in murine models of skin wound infection and peritoneal infection.

From: Naphthoquinone-derivative as a synthetic compound to overcome the antibiotic resistance of methicillin-resistant S. aureus

Fig. 6

a The effect of the treatment of 6c or vancomycin (via topical treatment, single dose at 4 mg/kg) on the bacterial burden in wounds of mice infected by MRSA at day 2 post-wounding (mean ± s.d, n = 3 mice per group) *p < 0.05 vs control. bf The effect of the treatment of 6c or vancomycin (via i.p injection, single dose at 15 mg/kg at day 2 post-infection) on the bacterial burden in lung (b), spleen (c), kidney (d), liver (e), and peritoneal (f) tissues of mice infected by MRSA (mean ± s.d, n = 8 mice per group). The CFU counts from homogenized tissue collected from each mouse was run in duplicates. *p < 0.05, **p < 0.01, and ***p < 0.001.

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