Fig. 1: Deep phylogenies of cancer driver genes.
From: Deep phylogeny of cancer drivers and compensatory mutations
Each row represents one species, each column one driver. Sites harboring multiple drivers appear multiple times. Colors correspond to mode residues over all sequences from each species in each site: white, absent from MSA; blue, gap; green, human reference residue; red, driver; gray, any other residue. Species are ordered by taxonomy, and within labeled clades, by appearance within # of MSA (e.g., a plant found to have orthologs in 310 drivers would occupy a row below another plant with 103). Sites are ordered by the phylogenetic depth of the respective genes. Only eukaryotes are shown, for prokaryotes see Supplementary Fig. 2. Rows are followed by box plots of the number of species within each clade observed across MSA where the given clade is represented. Whiskers are at 2/98%.
