Fig. 4: Select drivers are ancestral in major clades.
From: Deep phylogeny of cancer drivers and compensatory mutations
a Violin plots over major clades displaying the driver frequency among all sequences of each species where at least one sequence from that species harbors a driver. Median, 25th, and 75th percentiles of the species shown. Species that harbor multiple drivers are represented multiple times. b Left: frequencies of drivers harbored in “shallow” (MSA do not contain fungi or plants) sites among invertebrates vs. vertebrates and observed in both taxa. Right: frequencies of drivers harbored in “deep” sites among plants or fungi vs. metazoa and observed in both taxa. L&R, box plot of driver frequencies observed in one but not both respective taxa. Whiskers are at 2/98%. c Reduced MSA for driver gene KDM6A with drivers I776T and M806V highlighted.
