Fig. 5: Structures and associations among of cancer drivers.
From: Deep phylogeny of cancer drivers and compensatory mutations
a Association score, indicating the degree to which the co-occurrence frequency of a mutation-pair deviates from expectation if independent (+/−, more/less frequent) for select mutation pairs with large association scores in both COSMIC and the MSA. COSMIC association vs MSA association. Outliers in each quadrant are colored and listed. Bubble size scales with either the expected or observed number of pairs, whichever is smaller, across quantile normalized ex/obs distributions for both COSMIC and the MSA. See “Methods” for details. b Pie chart indicating the fraction of drivers with both a “good” structure (whole score >1) and at least one harboring species in the tree (20%), structure only (21%), tree only (35%), and neither (24%). c Coverage of driver/compensatory ensemble neighborhoods with structures scored (Local Score) 1.9 or greater. Dashed line, length of protein; gray band, PDB structure; red dots, driver location; green dots, compensator location. ATM is resolved in a single structure75 and split for display purposes.
