Fig. 6: Compensatory mutations for cancer drivers.
From: Deep phylogeny of cancer drivers and compensatory mutations
a Examples of direct, pairwise compensation where there is a single compensatory mutation which likely balances/counteracts the change induced by the driver. b Examples of compensatory ensembles which are likely to play a role in modifying small molecule binding pockets or protein interactions to offset the presence of the driver. (In NRAS, compensators not highlighted in structure to avoid clutter.) c Other examples. In CTCF, an aromatic interaction between the compensator and the driver is predicted to stabilize the protein. In PIK3CA (compensators not highlighted in structure to avoid clutter), localization of multiple drivers and compensators to two exterior neighborhoods of the large structure potentially important for protein interaction.
