Fig. 1: Mouse classic cadherin (Cdh) genomic organization and gene locations over chromosomes.
From: Redundant type II cadherins define neuroepithelial cell states for cytoarchitectonic robustness
a Mouse types I and II Cdh genomic organization are examined by using the UCSC genome browser (mm10) to be aligned over Cdh protein domain structure (For Type I, Cdh1~4 are selected as aligned in Supplementary Fig. 1a and for Type II, Cdh6~11 are chosen as shown in Supplementary Fig. 1b). Vertical bars attached to Cdh protein domain structure indicate shared positions of exon boundaries among each type. Note that respective type harbors distinct genomic organization. Asterisks show positions of conserved exon boundaries among all Cdhs, suggesting the differential evolutionary history for type I and type II subclasses. Scale bar, 100 amino acids (a.a.). b All Cdh gene locations over mouse/human chromosomes are searched by the UCSC genome browser (mm10 or hg19) and the mouse locations are arranged in the order of chromosomal number. Gene transcriptional directions are represented by arrows and only neighboring genes to each Cdh gene are included in this panel. Length of the chromosomal region abbreviated by long dashed lines is still precise in size. Below each Cdh gene name, defined Cdh types (i.e., I, IIa, IIa′, and IIb) and homophilic binding force (= the Kd value by μM) in vitro estimated by previous reports28,42,43 are indicated. Homophilic interactions among each Cdh subclass are predominant, yet occasional and weak heterophilic interactions could be observed in vitro as well as in vivo. This is remarkable among type II Cdh subclasses and their subgroups with like binding specificities defined in a recent report28 are painted by related colors: Cdh subclasses in type IIa share similar protein structure and binding specificities with those in type IIa′ to have a chance of heterophilic interactions, whereas Cdh subclasses in type IIb never interact with those in type IIa/a′. Type II Cdh subclasses in the same subgroup also have a possibility for heterophilic interactions. Noticeably, clustered type II Cdh genes tend to share similar binding specificities with each other. Scale bar, 1.0 mega base pairs (Mbp).
