Fig. 7: A schematic summary of our findings that focal adhesion-related RNPs are frequent and common humoral antigens in tumor microenvironments. | Communications Biology

Fig. 7: A schematic summary of our findings that focal adhesion-related RNPs are frequent and common humoral antigens in tumor microenvironments.

From: Focal adhesion ribonucleoprotein complex proteins are major humoral cancer antigens and targets in autoimmune diseases

Fig. 7

Focal adhesion machineries complexed with ribonucleoproteins and RNA molecules are frequent humoral antigens in tumor environments. This study suggested sequence-specific trafficking of RNA molecules to focal adhesion sites in cancer cells. Such focal adhesion complexes are occasionally exposed to the outside of cancer cells (red arrowhead) and/or may be broken down and deposited in necrotic cancer stromal environments (gray RNPs); thus, they are considered to trigger and expand B cell immunity in cancer microenvironments. TLR, Toll-like receptors; RNP, ribonucleoproteins.

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