Fig. 1: Correlation between lymphatic marker expression and MB aggressiveness.
From: VEGFC negatively regulates the growth and aggressiveness of medulloblastoma cells
a The amounts of VEGFC, NRP2, VEGFR3, LYVE1, PROX1 and PDPN genes were determined by analysis of the R2: Genomics Analysis and Visualization Platform (http://r2.amc.nl) data (One-way ANOVA and t-test for multiple comparison analysis; **p < 0.01; ***p < 0.001). b Analysis of a RNA-Seq tumor database (more than 250 patients) for overall survival of patients as a function of LYVE1 expression and patient’s subgroup of MB. Data were binned by 25% quartile. c Representative images (X 400) showing the expression of podoplanin (PDPN) in patient MB tissue, as a function of metastatic status. Paraffin-embedded tumor sections were labeled with an anti-PDPN antibody. PDPN focal labeling (*) and vessel-like structures (arrows) are indicated.
