Fig. 2: Main association results.

a Manhattan plot of the meta-analyses of both sexes (males: top, females: bottom). The horizontal red line indicates the genome-wide significance level (α = 5 × 10−9) on the −log10 scale. All significant SNPs are marked in green. b Per allele effect size versus minor allele frequency (MAF). The X-axis is the MAF of the 1059 identified variants, and the Y-axis is the per allele effect size (regression coefficient). The black solid line is the power function fitted to the data.